Garlic and ginkgo also increase the risk of bleeding because they cause bleeding when taken alone. Bleeding in the kidneys can cause back pain and blood in urine.ĭrug interactions of Coumadin which can increase the effect of Coumadin by reducing its breakdown in the body include:ĭrugs that may reduce the effect of Coumadin by increasing its breakdown include:īleeding is increased when Coumadin is taken with other anticoagulants, antiplatelet drugs such as aspirin and other nonsteroidal anti-inflammatory drugs ( NSAIDs), and serotonin reuptake inhibitors (SSRIs).Bleeding in the stomach or intestines can cause weakness, fainting spells, black tarry stools, vomiting of blood, or coffee ground material.Bleeding in the joints can cause joint pain and swelling.Bleeding around the brain can cause severe headache and paralysis.severe bleeding and necrosis ( gangrene) of the skin.Serious side effects of Coumadin include: yellowing of eyes and skin ( jaundice), and.
Coumadin is important in preventing the formation of blood clots, preventing extension of clots already formed, and minimizing the risk of embolization of blood clots to other vital organs such as the lungs and brain. Warfarin reduces the production of the factors because it antagonizes vitamin K. The production of these factors by the liver are dependent on adequate amounts of vitamin K. to prevent closure of coronary artery stents due to clotting.Ĭoumadin prevents the formation of blood clots by reducing the production of factors by the liver that promote clotting, factors II, VII, IX, and X, and the anticoagulant proteins C and S.to prevent blood clots from forming in certain orthopedic surgeries such as knee or hip replacements and.to reduce the risk of strokes, and after a heart attack in patients with atrial fibrillation or artificial heart valves.to prevent further emboli in patients with pulmonary embolism.treat deep vein thrombosis ( DVT) to prevent extension of the clot, and to reduce the risk of pulmonary embolism.Coumadin ( warfarin) is an oral anticoagulant, a drug that inhibits the clotting of blood.
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